Home Research paper For the unvaccinated, re-infection with COVID is likely

For the unvaccinated, re-infection with COVID is likely


“Reinfection can reasonably occur in three months or less,” Jeffrey Townsend, Elihu professor of biostatistics at the Yale School of Public Health and lead author of the study, said in a statement.

“Therefore, those who have been naturally infected should get vaccinated,” he said. “A previous infection alone may offer very little long-term protection against subsequent infections. “

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The Yale / North Carolina study, published in the journal The Lancet Microbe
, is the first to determine the likelihood of re-infection after natural infection and without vaccination, according to Yale.

Townsend and his team analyzed known reinfection and immunologic data from close relatives of SARS-CoV-2 virals that cause the ‘common cold’, as well as immunologic data from SARS-CoV-1 and Middle East respiratory syndrome “the university statement said. . “By leveraging evolutionary principles, the team was able to model the risk of re-infection with COVID-19 over time. “

“Reinfections can, and have occurred, even shortly after recovery,” the researchers said in the release. “And they will become more and more common as immunity wanes and new variants of SARS-CoV-2 emerge.”

“We tend to think of immunity as being immune or not immune. Our study warns that we should instead focus more on the risk of reinfection over time, ”said Alex Dornburg, assistant professor of bioinformatics and genomics at the University of North Carolina at Charlotte, who co-led the study, also in the press release.

“As new variants appear, the previous immune responses become less effective at fighting the virus,” Dornburg said. “Those who were naturally infected at the start of the pandemic are increasingly likely to be re-infected in the near future. “

The university further noted that the team’s “data-driven model reveals striking similarities with the risks of reinfection over time between SARS-CoV-2 and endemic coronaviruses.”

“Just like the common cold, year over year you can get re-infected with the same virus,” Townsend said. “The difference is, when it emerged in this pandemic, COVID-19 was found to be much more deadly. “

According to Townsend, “a hallmark of the modern world will be the evolution of new threats to human health.” .

In addition, he noted that the study results underscore the important role of evolutionary biology “in informing decision-making and constitute a crucial stepping stone towards a solid understanding of our prospects for resistance to SARS-CoV reinfection. -2 “.

The co-authors include researchers from Temple University. Research funding was provided by the US National Science Foundation, the statement said.