Home Scholarly articles Acta Pharmaceutica Sinica B Volume 11, Issue

Acta Pharmaceutica Sinica B Volume 11, Issue


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Acta Pharmaceutica Sinica B Volume 11, Number 12 Publications


Acta Pharmaceutica Sinica B (APSB) was founded with the aim of creating a high-level global forum focused on drug discovery and pharmaceutical research / application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation Index in 2017 and has evolved into one of the most important international journals in the field of pharmaceutical sciences.

APSB is a monthly journal, in English, which publishes important original research articles, rapid communications and high-quality journals on recent advances in all fields of pharmaceutical sciences – including pharmacology, pharmacy, medicinal chemistry , natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.

Special column on drug and chemical liver damage

This issue contains a special column entitled: Drug- and Chemical-Induced Liver Injury edited by James Luyendyk and Dafna Groeneveld, Department of Pathobiology and Diagnostic Investigation, Michigan State University East Lansing, MI, USA.



Articles of interest in this column include:

Dual role of p62 / SQSTM1 in the lesion and recovery phases of acetaminophen-induced liver damage in mice by Hui Qian, Qingyun Bai, XiaoYang et al. (https://doi.org/10.1016/j.apsb.2021.11.010). Overdose of acetaminophen (APAP) can induce liver damage and is the most common cause of acute liver failure in the United States. The authors of this article investigated the role of p62 / SQSTM1 (termed p62) in APAP-induced liver injury (AILI) in mice.

The key role of the gut-liver axis in hepatotoxicity and enterotoxicity induced by pyrrolizidine alkaloids by Yisheng He, Jiang Ma, Xiaoyu Fan et al. (https://doi.org/10.1016/j.apsb.2021.07.013). The authors of this article provide evidence for the mode of action of PA-induced enterotoxicity and stress the importance of intestinal barrier function in PA-induced liver injury.

Hepatotoxicity Reports in the FDA Adverse Event Reporting System Database: A Comparison of Drugs That Cause Damage Via Mitochondrial or Other Mechanisms by Payal Rana, Michael D. Aleo, Xuerong Wen and Stephen Kogut. (https://doi.org/10.1016/j.apsb.2021.05.028). Drug-induced mitochondrial toxicity (DILI) has been shown to play an essential role in various forms of DILI, particularly in idiosyncratic liver damage. This study examines reports of liver injury submitted to the Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) for drugs associated with hepatotoxicity via mitochondrial mechanisms versus non-mitochondrial toxicity mechanisms.

Other articles in the special section on drug and chemical liver injury include:

Revise articles

Preclinical Models of Drug-Induced Idiosyncratic Liver Injury (iDILI): Towards a Prediction

Antonio Segovia-Zafra, Daniel E. Di Zeo-Sánchez, Carlos López-Gómez, Zeus Pérez-Valdés, … Marina Villanueva-Paz

Mechanisms of hepatic damage induced by immune checkpoint inhibitors

Layla Shojaie, Myra Ali, Andrea Iorga, Lily Dara

Recommendations for using the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls

Hartmut Jaeschke, Olamide B. Adelusi, Jephte Y. Akakpo, Nga T. Nguyen et al.

Inappropriate mitochondrial changes induced by environmental toxicants: a potential unifying mechanism in fatty liver disease?

Regina D. Schnegelberger, Anna L. Lang, Gavin E. Arteel, Juliane I. Beier

Environmental exposure as a risk modifying factor in liver disease: Known and unknown

Juliane I. Beier, Gavin E. Arteel

Original articles

Mechanistic Studies of PEG-Asparaginase-Induced Liver Injury and Fatty Liver Disease in Mice

Gundala Venkata Naveen Kumar, Keito Hoshitsuki, Sanjay Rathod, Manda J. Ramsey et al.

Proteomics and Metabolic Phenotyping Define Primary Roles of Aryl Hydrocarbon Receptor in Mouse Liver

Jian Jin, Banrida Wahlang, Monika Thapa, Kimberly Z. Head et al.

Exogenous Phosphatidic Acid Reduces Acetaminophen-Induced Liver Damage in Mice by Activating Liver Interleukin-6 Signaling Through Inter-Organ Crosstalk

Melissa M. Clemens, Stefanie Kennon-McGill, Joel H. Vazquez, Owen W. Stephens et al.

Bile acid homeostasis in female mice deficient in Cyp7a1 and Cyp27a1

Daniel Rizzolo, Bo Kong, Rulaiha E. Taylor, Anita Brinker et al.

The altered pharmacokinetics of cisplatin in non-alcoholic steatohepatitis contributes to a reduction in nephrotoxicity

Joseph L. Jilek, Kayla L. Frost, Kevyn A. Jacobus, Wenxi He et al.

Other articles published in the issue include:

Revise articles

Entry of SARS-CoV-2 cells and targeted antiviral development

Zinuo Chen, Ruikun Du, Jazmin M. Galvan Achi, Lijun Rong, Qinghua Cui

Antibody-drug conjugates: recent advances in linker chemistry

Zheng Su, Dian Xiao, Fei Xie, Lianqi Liu et al.

Strategies for Overcoming Drug Resistance Using SHP2 Inhibitors

Meng Liu, Shan Gao, Reham M. Elhassan, Xuben Hou, Hao Fang

Original articles

A reporter gene test to determine the biological activity of therapeutic antibodies targeting TIGIT

Zhihao Fu, Hongchuan Liu, Lan Wang, Chuanfei Yu et al.

Inhibition of DNA-PK by M3814 Improves Chemosensitivity in Non-Small Cell Lung Cancer

Manni Wang, Siyuan Chen, Yuquan Wei, Xiawei Wei

The bioengineered miR-124-3p prodrug selectively modifies the proteome of human carcinoma cells to control multiple cell components and lung metastasis in vivo

Linglong Deng, Hannah Petrek, Mei-Juan Tu, Neelu Batra et al.

Synergistic effects of autophagy / mitophagy inhibitors and magnolol promote apoptosis and anti-tumor efficacy

Yancheng Tang, Liming Wang, Tao Yi, Jun Xu et al.

Small Molecule UPR Modulator for Diabetes Identified by High Throughput Screening

Valeria Marrocco, Tuan Tran, Siying Zhu, Seung Hyuk Choi et al.

TMEM16A inhibits angiotensin II-induced basilar artery smooth muscle cell migration in a WNK1-dependent manner

Huaqing Zheng, Xiaolong Li, Xin Zeng, Chengcui Huang et al.

JOSD2 deubiquitinase stabilizes YAP / TAZ to promote progression of cholangiocarcinoma

Meijia Qian, Fangjie Yan, Weihua Wang, Jiamin Du et al.

Target-sensitive subcellular catabolism assay for screening and evaluation of early stage antibody-drug conjugates

Hua Sang, Jiali Liu, Fang Zhou, Xiaofang Zhang et al.

A nanocleaner specifically penetrates the blood-brain barrier at lesions to cleanse toxic proteins and regulate inflammation in Alzheimer’s disease

Ting Lei, Zhihang Yang, Xue Xia, Yuxiu Chen et al.

Short communication

Baicalin induces ferroptosis in bladder cancer cells by down-regulating FTH1

Na Kong, Xiaying Chen, Jiao Feng, Ting Duan et al.

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The Journal of Institute of Materia Medica, Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.

For more information, please visit https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/

Editorial board: https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/editorial-board

APSB is available on ScienceDirect (https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b).

Submissions to APSB can be done using Editorial manager® (https://www.editorialmanager.com/apsb/default.aspx).

CiteScore: 12.5

Impact factor: 11.614

JIF without self-citation: 10.746

ISSN 2211-3835

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